Blockade of Episodic Secretion of Luteinizing Hormone in the Ram by the Administration of Antibodies to Luteinizing Hormone Releasing Hormone
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چکیده
منابع مشابه
Luteinizing hormone-releasing hormone antagonists.
BACKGROUND Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications. OBJECTIVE/METHOD Here we give an overview of the most r...
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Fractionation of hypothalamic extracts on a Sephadex G-25 column separates follicle-stimulating hormone-releasing factor (FSHRF) from luteinizing hormone-releasing hormone (LHRH). The FSH-releasing peak contained immunoreactive lamprey gonadotropin-releasing hormone (lGnRH) by radioimmunoassay, and its activity was inactivated by an antiserum specific to lGnRH. The identity of lGnRH-III with FS...
متن کاملLuteinizing hormone-releasing hormone neurons express Fos protein during the proestrous surge of luteinizing hormone.
The ability of luteinizing hormone-releasing hormone (LHRH) neurons to express the oncogene c-fos was examined during the estrous cycle in rats. The immunocytochemical localization of the c-fos-encoded antigen, Fos, was coupled with the immunocytochemical localization of LHRH. LHRH neurons showed no Fos immunoreactivity during diestrus-1, diestrus-2, estrus, or the morning of proestrus. However...
متن کاملThe response to luteinizing hormone-releasing hormone in normal men.
Synthetic luteinizing hormone-releasing hormone (LH-RH) was given in doses of 11-100 Vg to normal men. Doses of 50 and 100 t±g caused a twoto ten-fold rise in serum LH in all subjects, but in only 40% was the serum follicle-stimulating hormone (FSH) elevated. A significantly higher LH response to LHRH was seen in subjects in whom a rise in serum FSH could be detected. Although there was a wide ...
متن کاملStudies on the properties of hypothalamic luteinizing hormone-releasing hormone.
The effects of various chemical and enzymatic treatments on the biological activity of porcine luteinizing hormone-releasing hormone (LH-RH) are described. This experiment was performed before the elucidation of the structure of LH-RH. LH-RH activity was abolished by the following endopeptidases: chymotrypsin, subtilisin, papain, and thermolysin, but not by pepsin or trypsin. Exopeptidases d...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1979
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod21.5.1239